To evaluate the utility of nude mouse xenografts as preclinical drug screens, the activity of ten established chemotherapeutic agents was evaluated against seven melanoma and three ovarian carcinoma xenografts. Xenografts were established using primary explants from patients who had not received chemotherapy and serially passaged as sc tumors in nude mice. Plots of relative tumor growth versus time were nearly log-linear. Both modes of data analysis identified alkylating agents melphalan, carmustine, and mitomycin as the most active drugs against human melanomas.
Meet flakka, the drug police say is making people run around nude and have sex with trees
Dangerous drug flakka turning people into naked, paranoid lunatics - Business Insider
Subscriber Account active since. A February 12 photo made available by the Broward Sheriff's Office in Florida showing confiscated vials of flakka. This drug can alter brain chemistry in such a way that users can't control their thoughts, and it can increase adrenaline. Another ran nude down a busy city street in broad daylight, convinced a pack of German shepherds was pursuing him. Two others tried separately to break into the Fort Lauderdale Police Department.
Human tumors transplanted into nude mice have long been used to assess the effectiveness of antitumor drugs and yet there is still no established standard method in preclinical practice for screening new antitumor drugs in vivo using nude mice. Two human stomach cancers, H and SCJCK, and one human colon cancer, Co-4, were transplanted serially into nude mice and used as gastrointestinal tract tumors with stable tumor growth. The appropriate dosage of six well-known antitumor drugs [mitomycin C MMC , cyclophosphamide CPA , nimustine hydrochloride 1- 4-aminomethylpyrimidinyl methyl 2-chloroethyl nitrosourea hydrochloride ACNU , cis-platinum II diaminodichloride CDDP , adriamycin ADM and 5-fluorouracil 5-FU ] in human tumor-bearing nude mice was determined based on the maximum tolerance dose of the drug. Three weeks after treatment, drug effectiveness was judged by the tumor growth inhibition rate. Treatment with these appropriate doses appeared to show the maximum effect of the respective drugs on the tumor-bearing nude mice.
Patient tumor explants established subcutaneously in serial passage in nude mice were characterized for their sensitivity towards 11 standard cytotoxic anti-cancer agents. The latter include the alkylating agents cyclophosphamide, ifosfamide, mitomycin C, cisplatin and CCNU, the antimetabolites 5-FU and methotrexate; the topoisomerase II inhibitors adriamycin and etoposide, as well as the tubulin binders paclitaxel and vindesine. The mean number of tumors treated with any of the various drugs was 54 range The tumor xenografts' gene expression profiles were determined using the Affymetrix HG-U plus 2.