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Previously we showed that unlike normal, nude, or X-linked immune deficient xid mice, nude. We show that nude. These results correlated with the observation that in nude. Thus the combination of the nude and xid mutations produces a deficiency in early B cell progenitors and the deficiency becomes more profound with further maturation. Therefore the lack of mature B cells is the result of a cascade effect. Inasmuch as bone marrow progenitors are affected, and these are the source of the vast majority of B cells, most B cells are affected by the xid mutation and the xid defect cannot be attributed to a loss of a fetal lineage of B cells.
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Comments
  •   Faum June 6, 2019
    Anyone have the source for 0:32?
    +18 -15
 
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